Drug interactions
Asenapine + Codeine
Severity: Moderate
Asenapine and Codeine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is sedating and combined with codeine can increase drowsiness, dizziness and orthostatic hypotension. Respiratory depression is possible at higher opioid doses.
What this interaction means in plain words
Asenapine and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Codeine belongs to Musculoskeletal.
Why it happens
Additive CNS depression through pharmacodynamic synergism.
What to do
Start with low doses and monitor sedation, blood pressure and breathing. Counsel patients on impaired alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Codeine
- Alvimopan + Codeine Contraindicated
- Codeine + Isocarboxazid Contraindicated
- Codeine + Olanzapine / samidorphan Contraindicated
- Codeine + Phenelzine Contraindicated
- Codeine + Tranylcypromine Contraindicated
- Alfentanil + Codeine Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Codeine?
MediHelp rates the interaction as moderate. Asenapine and Codeine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is sedating and combined with codeine can increase drowsiness, dizziness and orthostatic hypotension. Respiratory depression is possible at higher opioid doses.
How serious is the interaction between Asenapine and Codeine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor sedation, blood pressure and breathing. Counsel patients on impaired alertness.
What other medicines interact with Codeine?
MediHelp also lists interactions of Codeine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Codeine page.
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