Drug interactions
Asenapine + Degarelix
Severity: Moderate
Asenapine and Degarelix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as degarelix can prolong the QT interval, and asenapine adds to this effect. The risk is greater in patients with existing cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Asenapine and Degarelix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Degarelix belongs to Endocrine.
Why it happens
Additive pharmacodynamic QTc prolongation.
What to do
Obtain baseline ECG and correct electrolytes. Monitor ECG periodically and consider a lower-risk antipsychotic if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Asenapine with Degarelix?
MediHelp rates the interaction as moderate. Asenapine and Degarelix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as degarelix can prolong the QT interval, and asenapine adds to this effect. The risk is greater in patients with existing cardiac disease or electrolyte abnormalities.
How serious is the interaction between Asenapine and Degarelix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and correct electrolytes. Monitor ECG periodically and consider a lower-risk antipsychotic if QTc becomes prolonged.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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