Drug interactions
Asenapine + Dimenhydrinate
Severity: Moderate
Asenapine and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate, which releases diphenhydramine, is sedating and anticholinergic. With asenapine it can cause additive drowsiness and impaired psychomotor performance.
What this interaction means in plain words
Asenapine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive CNS depression via H1 antagonism and added anticholinergic effects.
What to do
Limit use and counsel on drowsiness; avoid alcohol and driving after doses. Choose a less sedating option when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Asenapine with Dimenhydrinate?
MediHelp rates the interaction as moderate. Asenapine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate, which releases diphenhydramine, is sedating and anticholinergic. With asenapine it can cause additive drowsiness and impaired psychomotor performance.
How serious is the interaction between Asenapine and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use and counsel on drowsiness; avoid alcohol and driving after doses. Choose a less sedating option when possible.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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