Drug interactions
Asenapine + Empagliflozin-metformin
Severity: Moderate
Asenapine and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can raise blood glucose and worsen glycemic control in some patients. This may reduce the effectiveness of empagliflozin-metformin in people with diabetes.
What this interaction means in plain words
Asenapine and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: atypical antipsychotics can cause insulin resistance and hyperglycemia, opposing the glucose-lowering effect of the antidiabetic drugs.
What to do
Monitor fasting glucose and HbA1c when asenapine is started or changed, and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Asenapine and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can raise blood glucose and worsen glycemic control in some patients. This may reduce the effectiveness of empagliflozin-metformin in people with diabetes.
How serious is the interaction between Asenapine and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c when asenapine is started or changed, and adjust the antidiabetic regimen as needed.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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