Drug interactions
Asenapine + Ezogabine
Severity: Moderate
Asenapine and Ezogabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine can cause modest QT prolongation, and asenapine also carries a QT-prolonging potential. Combined use could increase the risk of ventricular arrhythmia, particularly at higher ezogabine doses or with other risk factors.
What this interaction means in plain words
Asenapine and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Ezogabine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG and repeat after dose changes. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Ezogabine
Frequently asked questions
Can I take Asenapine with Ezogabine?
MediHelp rates the interaction as moderate. Asenapine and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine can cause modest QT prolongation, and asenapine also carries a QT-prolonging potential. Combined use could increase the risk of ventricular arrhythmia, particularly at higher ezogabine doses or with other risk factors.
How serious is the interaction between Asenapine and Ezogabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after dose changes. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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