Drug interactions
Asenapine + Galantamine
Severity: Minor
Asenapine and Galantamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is a weak CYP2D6 inhibitor and galantamine is partly metabolized by CYP2D6, so galantamine exposure may rise slightly. The effect is unlikely to be clinically important, though cholinergic and antipsychotic pharmacodynamic opposition is possible.
What this interaction means in plain words
Asenapine and Galantamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Galantamine belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition by asenapine reduces galantamine clearance.
What to do
No dose adjustment is usually required; monitor for cholinergic effects such as nausea and bradycardia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Asenapine with Galantamine?
MediHelp rates the interaction as minor. Asenapine and Galantamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Asenapine is a weak CYP2D6 inhibitor and galantamine is partly metabolized by CYP2D6, so galantamine exposure may rise slightly. The effect is unlikely to be clinically important, though cholinergic and antipsychotic pharmacodynamic opposition is possible.
How serious is the interaction between Asenapine and Galantamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for cholinergic effects such as nausea and bradycardia.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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