Drug interactions
Asenapine + Ganaxolone
Severity: Moderate
Asenapine and Ganaxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone causes somnolence and sedation, which may be intensified by asenapine. Impaired alertness and falls are the main concern.
What this interaction means in plain words
Asenapine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Ganaxolone belongs to Central Nervous System.
Why it happens
Additive CNS depression (GABA-A positive modulation plus antipsychotic sedation).
What to do
Monitor for excessive sedation and consider reducing the dose of ganaxolone or asenapine if it occurs. Advise caution with driving and other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Asenapine with Ganaxolone?
MediHelp rates the interaction as moderate. Asenapine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone causes somnolence and sedation, which may be intensified by asenapine. Impaired alertness and falls are the main concern.
How serious is the interaction between Asenapine and Ganaxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider reducing the dose of ganaxolone or asenapine if it occurs. Advise caution with driving and other CNS depressants.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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