Drug interactions
Asenapine + Gliclazide
Severity: Moderate
Asenapine and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can raise blood glucose and may impair diabetes control in patients taking gliclazide. Hyperglycemia, occasionally severe, has been reported with atypical antipsychotics.
What this interaction means in plain words
Asenapine and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Gliclazide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism due to antipsychotic-associated insulin resistance and impaired glucose regulation.
What to do
Check glucose and HbA1c at baseline and periodically during asenapine therapy. Increase or adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Gliclazide?
MediHelp rates the interaction as moderate. Asenapine and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can raise blood glucose and may impair diabetes control in patients taking gliclazide. Hyperglycemia, occasionally severe, has been reported with atypical antipsychotics.
How serious is the interaction between Asenapine and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose and HbA1c at baseline and periodically during asenapine therapy. Increase or adjust antidiabetic therapy if control worsens.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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