Drug interactions
Asenapine + Insulin degludec-liraglutide
Severity: Moderate
Asenapine and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can disturb glucose metabolism and cause hyperglycemia in some patients. This may reduce the effectiveness of insulin degludec-liraglutide and make glycemic control less predictable.
What this interaction means in plain words
Asenapine and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Atypical antipsychotics may induce insulin resistance and impair glucose regulation, opposing the effect of antidiabetic drugs.
What to do
Monitor blood glucose more frequently after starting asenapine or changing its dose, and titrate the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Asenapine and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can disturb glucose metabolism and cause hyperglycemia in some patients. This may reduce the effectiveness of insulin degludec-liraglutide and make glycemic control less predictable.
How serious is the interaction between Asenapine and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting asenapine or changing its dose, and titrate the antidiabetic regimen as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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