Drug interactions
Asenapine + Insulin degludec
Severity: Moderate
Asenapine and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can worsen glucose tolerance and cause hyperglycemia, which may offset the effect of insulin degludec. Higher insulin doses may be needed.
What this interaction means in plain words
Asenapine and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Insulin degludec belongs to Endocrine.
Why it happens
Antipsychotic-associated insulin resistance and metabolic effects oppose insulin action; the exact mechanism is not fully established.
What to do
Increase glucose monitoring after starting or adjusting asenapine. Adjust the basal insulin dose according to results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Asenapine with Insulin degludec?
MediHelp rates the interaction as moderate. Asenapine and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can worsen glucose tolerance and cause hyperglycemia, which may offset the effect of insulin degludec. Higher insulin doses may be needed.
How serious is the interaction between Asenapine and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase glucose monitoring after starting or adjusting asenapine. Adjust the basal insulin dose according to results.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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