Drug interactions
Asenapine + Insulin glargine-lixisenatide
Severity: Moderate
Asenapine and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine, like other atypical antipsychotics, may cause hyperglycemia and impair glycemic control in patients with diabetes. This can counteract the effect of insulin and lixisenatide and increase the dose needed.
What this interaction means in plain words
Asenapine and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Pharmacodynamic opposition; antipsychotic-induced insulin resistance and altered glucose regulation.
What to do
Monitor blood glucose and HbA1c regularly after starting asenapine and adjust the antidiabetic doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Asenapine and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine, like other atypical antipsychotics, may cause hyperglycemia and impair glycemic control in patients with diabetes. This can counteract the effect of insulin and lixisenatide and increase the dose needed.
How serious is the interaction between Asenapine and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly after starting asenapine and adjust the antidiabetic doses.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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