Drug interactions
Asenapine + Isoflurane
Severity: Moderate
Asenapine and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval during anesthesia, and asenapine adds to this effect. The risk of perioperative arrhythmia may be increased, especially with electrolyte disturbances.
What this interaction means in plain words
Asenapine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation; volatile anesthetics delay ventricular repolarization.
What to do
Review the preoperative ECG and correct potassium and magnesium before surgery. Monitor the ECG continuously during anesthesia and have arrhythmia treatment available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Asenapine with Isoflurane?
MediHelp rates the interaction as moderate. Asenapine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval during anesthesia, and asenapine adds to this effect. The risk of perioperative arrhythmia may be increased, especially with electrolyte disturbances.
How serious is the interaction between Asenapine and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the preoperative ECG and correct potassium and magnesium before surgery. Monitor the ECG continuously during anesthesia and have arrhythmia treatment available.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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