Drug interactions
Asenapine + Lisinopril
Severity: Moderate
Asenapine and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension, particularly at initiation. With lisinopril the blood pressure fall may be exaggerated, raising the risk of dizziness, syncope and falls.
What this interaction means in plain words
Asenapine and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Lisinopril belongs to Cardiovascular.
Why it happens
Additive hypotension from ACE inhibition and alpha-1 adrenergic antagonism by asenapine.
What to do
Monitor blood pressure and orthostatic symptoms when starting asenapine or increasing the dose. Adjust the antihypertensive dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Lisinopril?
MediHelp rates the interaction as moderate. Asenapine and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension, particularly at initiation. With lisinopril the blood pressure fall may be exaggerated, raising the risk of dizziness, syncope and falls.
How serious is the interaction between Asenapine and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting asenapine or increasing the dose. Adjust the antihypertensive dose if needed.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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