Drug interactions
Asenapine + Lorazepam
Severity: Moderate
Asenapine and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine causes somnolence and orthostatic effects, and with lorazepam these can be additive. Impaired alertness and falls are the main concerns.
What this interaction means in plain words
Asenapine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through antipsychotic receptor blockade and GABA-A potentiation.
What to do
Monitor for sedation and orthostatic hypotension, especially when starting treatment. Reduce doses if excessive drowsiness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Lorazepam?
MediHelp rates the interaction as moderate. Asenapine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine causes somnolence and orthostatic effects, and with lorazepam these can be additive. Impaired alertness and falls are the main concerns.
How serious is the interaction between Asenapine and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension, especially when starting treatment. Reduce doses if excessive drowsiness develops.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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