Drug interactions
Asenapine + Metformin-repaglinide
Severity: Minor
Asenapine and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics may impair glucose tolerance and weaken the effect of antidiabetic drugs. Asenapine has been associated with modest metabolic changes.
What this interaction means in plain words
Asenapine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Metformin-repaglinide belongs to Endocrine.
Why it happens
Antipsychotic-related insulin resistance may oppose antidiabetic effects.
What to do
Monitor glucose and HbA1c after starting asenapine and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Metformin-repaglinide?
MediHelp rates the interaction as minor. Asenapine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atypical antipsychotics may impair glucose tolerance and weaken the effect of antidiabetic drugs. Asenapine has been associated with modest metabolic changes.
How serious is the interaction between Asenapine and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting asenapine and adjust antidiabetic therapy as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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