Drug interactions
Asenapine + Moexipril
Severity: Moderate
Asenapine and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine has alpha-adrenergic blocking activity that can cause orthostatic hypotension. Combined with an ACE inhibitor, blood pressure may fall more than expected, particularly at initiation.
What this interaction means in plain words
Asenapine and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Moexipril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-1 blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when either drug is started or the dose increased. Adjust the antihypertensive dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Moexipril?
MediHelp rates the interaction as moderate. Asenapine and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine has alpha-adrenergic blocking activity that can cause orthostatic hypotension. Combined with an ACE inhibitor, blood pressure may fall more than expected, particularly at initiation.
How serious is the interaction between Asenapine and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when either drug is started or the dose increased. Adjust the antihypertensive dose if needed.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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