Drug interactions
Asenapine + Morphine
Severity: Moderate
Asenapine and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is sedating and can cause orthostatic hypotension, so with morphine it may produce additive drowsiness, hypotension and respiratory depression. Older patients and those with respiratory compromise are most vulnerable.
What this interaction means in plain words
Asenapine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotensive effects from opioid agonism and antipsychotic receptor antagonism.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Counsel on avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Morphine?
MediHelp rates the interaction as moderate. Asenapine and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is sedating and can cause orthostatic hypotension, so with morphine it may produce additive drowsiness, hypotension and respiratory depression. Older patients and those with respiratory compromise are most vulnerable.
How serious is the interaction between Asenapine and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Counsel on avoiding driving and alcohol.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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