Drug interactions
Asenapine + Nateglinide
Severity: Moderate
Asenapine and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine may impair glucose tolerance and raise blood glucose, which can reduce the effect of nateglinide. Diabetes control may need reassessment after the antipsychotic is started.
What this interaction means in plain words
Asenapine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Nateglinide belongs to Endocrine.
Why it happens
Antipsychotic-associated insulin resistance and metabolic effects oppose the insulin secretagogue; the exact mechanism is not fully established.
What to do
Monitor blood glucose and HbA1c more frequently after starting or changing asenapine. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Asenapine with Nateglinide?
MediHelp rates the interaction as moderate. Asenapine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine may impair glucose tolerance and raise blood glucose, which can reduce the effect of nateglinide. Diabetes control may need reassessment after the antipsychotic is started.
How serious is the interaction between Asenapine and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c more frequently after starting or changing asenapine. Adjust the antidiabetic regimen as needed.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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