Drug interactions
Asenapine + Nilotinib
Severity: Major
Asenapine and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib has a boxed warning for QT prolongation and sudden death, and asenapine also prolongs the QT interval. Using them together substantially increases the risk of life-threatening arrhythmia.
What this interaction means in plain words
Asenapine and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Avoid the combination and choose an antipsychotic with less QT effect if possible. If it cannot be avoided, perform frequent ECG monitoring, maintain normal potassium and magnesium, and reduce or hold nilotinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Asenapine with Nilotinib?
MediHelp rates the interaction as major. Asenapine and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib has a boxed warning for QT prolongation and sudden death, and asenapine also prolongs the QT interval. Using them together substantially increases the risk of life-threatening arrhythmia.
How serious is the interaction between Asenapine and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic with less QT effect if possible. If it cannot be avoided, perform frequent ECG monitoring, maintain normal potassium and magnesium, and reduce or hold nilotinib if QTc becomes markedly prolonged.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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