Drug interactions
Asenapine + Paroxetine
Severity: Moderate
Asenapine and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can modestly prolong QTc, and paroxetine has little QT effect itself. Paroxetine also inhibits CYP2D6 and may slightly raise asenapine exposure, though the clinical impact is limited.
What this interaction means in plain words
Asenapine and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Paroxetine belongs to Central Nervous System.
Why it happens
Possible additive QTc effect and weak pharmacokinetic effect via CYP2D6 inhibition.
What to do
Monitor ECG in patients with cardiac risk factors and keep potassium and magnesium normal. Observe for increased sedation or adverse effects of asenapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Paroxetine?
MediHelp rates the interaction as moderate. Asenapine and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can modestly prolong QTc, and paroxetine has little QT effect itself. Paroxetine also inhibits CYP2D6 and may slightly raise asenapine exposure, though the clinical impact is limited.
How serious is the interaction between Asenapine and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and keep potassium and magnesium normal. Observe for increased sedation or adverse effects of asenapine.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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