Drug interactions
Asenapine + Phenelzine
Severity: Moderate
Asenapine and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine with an MAOI may produce additive hypotension and sedation, and rarely serotonin syndrome or neuroleptic malignant syndrome. Clinical reports are limited.
What this interaction means in plain words
Asenapine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Asenapine's serotonin and dopamine receptor antagonism may add to the increased monoamine levels from MAO inhibition, along with additive hypotensive effects.
What to do
Monitor blood pressure and for features of serotonin toxicity or neuroleptic malignant syndrome, especially at initiation and dose changes. Stop one agent if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Phenelzine?
MediHelp rates the interaction as moderate. Asenapine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine with an MAOI may produce additive hypotension and sedation, and rarely serotonin syndrome or neuroleptic malignant syndrome. Clinical reports are limited.
How serious is the interaction between Asenapine and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for features of serotonin toxicity or neuroleptic malignant syndrome, especially at initiation and dose changes. Stop one agent if toxicity is suspected.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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