Drug interactions
Asenapine + Repaglinide
Severity: Moderate
Asenapine and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can impair glucose tolerance and raise blood glucose, which may offset the glucose-lowering effect of repaglinide. Diabetes control may worsen after asenapine is started.
What this interaction means in plain words
Asenapine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Repaglinide belongs to Endocrine.
Why it happens
Antipsychotic-related insulin resistance and metabolic effects oppose antidiabetic action (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c at baseline and periodically during treatment. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Asenapine with Repaglinide?
MediHelp rates the interaction as moderate. Asenapine and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can impair glucose tolerance and raise blood glucose, which may offset the glucose-lowering effect of repaglinide. Diabetes control may worsen after asenapine is started.
How serious is the interaction between Asenapine and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c at baseline and periodically during treatment. Adjust the antidiabetic regimen as needed.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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