Drug interactions
Asenapine + Safinamide
Severity: Moderate
Asenapine and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine blocks dopamine receptors and may counteract the dopaminergic benefit of safinamide in Parkinson disease. This can worsen motor symptoms.
What this interaction means in plain words
Asenapine and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between dopamine D2 receptor blockade and enhancement of dopaminergic transmission.
What to do
Avoid dopamine antagonists in Parkinson disease when possible. If an antipsychotic is needed, choose one with minimal D2 blockade such as quetiapine, clozapine or pimavanserin, and monitor motor function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Asenapine with Safinamide?
MediHelp rates the interaction as moderate. Asenapine and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine blocks dopamine receptors and may counteract the dopaminergic benefit of safinamide in Parkinson disease. This can worsen motor symptoms.
How serious is the interaction between Asenapine and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid dopamine antagonists in Parkinson disease when possible. If an antipsychotic is needed, choose one with minimal D2 blockade such as quetiapine, clozapine or pimavanserin, and monitor motor function.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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