Drug interactions
Asenapine + Selegiline
Severity: Moderate
Asenapine and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO-B inhibitor that is less selective at higher doses, and its combination with an antipsychotic may increase the risk of serotonin toxicity or neuroleptic malignant syndrome. Antipsychotic dopamine blockade also opposes selegiline's dopaminergic effect in Parkinson's disease.
What this interaction means in plain words
Asenapine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
MAO inhibition combined with dopamine D2 and serotonin receptor antagonism; pharmacodynamic opposition of dopaminergic therapy.
What to do
Monitor for agitation, fever, rigidity, tremor and autonomic instability, and for worsening Parkinsonian motor symptoms. Stop the drugs if serotonin toxicity or neuroleptic malignant syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Asenapine with Selegiline?
MediHelp rates the interaction as moderate. Asenapine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is an MAO-B inhibitor that is less selective at higher doses, and its combination with an antipsychotic may increase the risk of serotonin toxicity or neuroleptic malignant syndrome. Antipsychotic dopamine blockade also opposes selegiline's dopaminergic effect in Parkinson's disease.
How serious is the interaction between Asenapine and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, fever, rigidity, tremor and autonomic instability, and for worsening Parkinsonian motor symptoms. Stop the drugs if serotonin toxicity or neuroleptic malignant syndrome is suspected.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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