Drug interactions
Asenapine + Tadalafil
Severity: Moderate
Asenapine and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension through alpha-1 blockade, and tadalafil's vasodilating action may add to this. Patients may experience dizziness or syncope.
What this interaction means in plain words
Asenapine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Tadalafil belongs to Genitourinary.
Why it happens
Additive hypotensive effects from PDE5 inhibition and antipsychotic alpha-adrenergic antagonism.
What to do
Monitor blood pressure and orthostatic symptoms when combining, and counsel patients to rise slowly. Use the lowest effective tadalafil dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Tadalafil?
MediHelp rates the interaction as moderate. Asenapine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension through alpha-1 blockade, and tadalafil's vasodilating action may add to this. Patients may experience dizziness or syncope.
How serious is the interaction between Asenapine and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when combining, and counsel patients to rise slowly. Use the lowest effective tadalafil dose.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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