Drug interactions
Asenapine + Terazosin
Severity: Moderate
Asenapine and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine has alpha-1 adrenergic antagonist activity and can cause orthostatic hypotension and syncope. Combined with terazosin, the hypotensive effect may be additive, raising the risk of falls.
What this interaction means in plain words
Asenapine and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Terazosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic receptor blockade producing vasodilation and orthostatic hypotension.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Consider reducing the terazosin dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Terazosin?
MediHelp rates the interaction as moderate. Asenapine and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine has alpha-1 adrenergic antagonist activity and can cause orthostatic hypotension and syncope. Combined with terazosin, the hypotensive effect may be additive, raising the risk of falls.
How serious is the interaction between Asenapine and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Consider reducing the terazosin dose if symptomatic hypotension develops.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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