Drug interactions
Asenapine + Timolol
Severity: Moderate
Asenapine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension and is a weak CYP2D6 inhibitor, which might slightly raise timolol exposure. Together, additive hypotension and bradycardia are possible.
What this interaction means in plain words
Asenapine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Additive hypotensive effects, with possible weak CYP2D6 inhibition by asenapine reducing timolol clearance.
What to do
Monitor blood pressure, heart rate and orthostatic symptoms during initiation, and lower the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Timolol?
MediHelp rates the interaction as moderate. Asenapine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension and is a weak CYP2D6 inhibitor, which might slightly raise timolol exposure. Together, additive hypotension and bradycardia are possible.
How serious is the interaction between Asenapine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and orthostatic symptoms during initiation, and lower the antihypertensive dose if hypotension occurs.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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