Drug interactions
Asenapine + Tolterodine
Severity: Minor
Asenapine and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is a weak CYP2D6 inhibitor and may modestly raise tolterodine levels. Both drugs have anticholinergic and QT-related effects, which may be additive.
What this interaction means in plain words
Asenapine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Weak CYP2D6 inhibition by asenapine plus additive anticholinergic and QT effects.
What to do
Monitor for anticholinergic effects and consider ECG monitoring if other QT risk factors exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Tolterodine?
MediHelp rates the interaction as minor. Asenapine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Asenapine is a weak CYP2D6 inhibitor and may modestly raise tolterodine levels. Both drugs have anticholinergic and QT-related effects, which may be additive.
How serious is the interaction between Asenapine and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and consider ECG monitoring if other QT risk factors exist.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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