Drug interactions
Asenapine transdermal + Desipramine
Severity: Moderate
Asenapine transdermal and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval and cause sedation. Combined use raises the potential for arrhythmia and additive CNS depression.
What this interaction means in plain words
Asenapine transdermal and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and CNS depressant effects.
What to do
Check a baseline ECG and electrolytes and monitor the QTc, especially after dose changes. Watch for excessive sedation and orthostasis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Desipramine?
MediHelp rates the interaction as moderate. Asenapine transdermal and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval and cause sedation. Combined use raises the potential for arrhythmia and additive CNS depression.
How serious is the interaction between Asenapine transdermal and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor the QTc, especially after dose changes. Watch for excessive sedation and orthostasis.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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