Drug interactions
Asenapine transdermal + Fluticasone-vilanterol
Severity: Moderate
Asenapine transdermal and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can prolong the QT interval, and vilanterol may add cardiac effects through beta-agonist activity. The combination may increase the chance of arrhythmia in susceptible patients.
What this interaction means in plain words
Asenapine transdermal and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation with beta2-adrenergic cardiovascular stimulation.
What to do
Monitor ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Asenapine transdermal with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Asenapine transdermal and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can prolong the QT interval, and vilanterol may add cardiac effects through beta-agonist activity. The combination may increase the chance of arrhythmia in susceptible patients.
How serious is the interaction between Asenapine transdermal and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Use the lowest effective doses.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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