Drug interactions
Asenapine transdermal + Oxymorphone
Severity: Moderate
Asenapine transdermal and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is sedating and can add to the CNS depressant effects of opioids. Drowsiness, orthostatic hypotension and impaired psychomotor function may be increased.
What this interaction means in plain words
Asenapine transdermal and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from antipsychotic sedative properties and opioid agonism.
What to do
Monitor for sedation, hypotension and respiratory depression, especially at initiation or dose increases. Use the lowest effective opioid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Oxymorphone?
MediHelp rates the interaction as moderate. Asenapine transdermal and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is sedating and can add to the CNS depressant effects of opioids. Drowsiness, orthostatic hypotension and impaired psychomotor function may be increased.
How serious is the interaction between Asenapine transdermal and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension and respiratory depression, especially at initiation or dose increases. Use the lowest effective opioid dose.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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