Drug interactions
Asenapine transdermal + Sertraline
Severity: Moderate
Asenapine transdermal and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine has a modest QT-prolonging effect, and sertraline may add a small additional effect. Sertraline may also modestly raise asenapine exposure. The overall risk is limited but meaningful in patients with other QT risk factors.
What this interaction means in plain words
Asenapine transdermal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with possible CYP inhibition by sertraline increasing asenapine levels.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct electrolytes. Monitor for palpitations or syncope, and review the combination if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Sertraline?
MediHelp rates the interaction as moderate. Asenapine transdermal and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine has a modest QT-prolonging effect, and sertraline may add a small additional effect. Sertraline may also modestly raise asenapine exposure. The overall risk is limited but meaningful in patients with other QT risk factors.
How serious is the interaction between Asenapine transdermal and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct electrolytes. Monitor for palpitations or syncope, and review the combination if QTc lengthens.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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