Drug interactions
Asenapine transdermal + Ziprasidone
Severity: Major
Asenapine transdermal and Ziprasidone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antipsychotics associated with QT prolongation, so combining them increases the risk of torsades de pointes. Using two antipsychotics also adds to sedation and extrapyramidal effects without clear benefit.
What this interaction means in plain words
Asenapine transdermal and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation.
What to do
Avoid combining the two antipsychotics; if a switch is being made, cross-taper and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Ziprasidone?
MediHelp rates the interaction as major. Asenapine transdermal and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are antipsychotics associated with QT prolongation, so combining them increases the risk of torsades de pointes. Using two antipsychotics also adds to sedation and extrapyramidal effects without clear benefit.
How serious is the interaction between Asenapine transdermal and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two antipsychotics; if a switch is being made, cross-taper and monitor ECG and electrolytes.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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