Drug interactions
Ashwagandha + Cyclizine
Severity: Minor
Ashwagandha and Cyclizine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ashwagandha has reported sedative properties and may add to the drowsiness caused by cyclizine. The clinical significance is uncertain and is based mainly on theoretical grounds.
What this interaction means in plain words
Ashwagandha and Cyclizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive sedation, with ashwagandha thought to act on GABAergic pathways; the mechanism is not firmly established.
What to do
Advise patients to watch for excess drowsiness and avoid driving until they know how the combination affects them. Reduce or stop the herbal product if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Ashwagandha with Cyclizine?
MediHelp rates the interaction as minor. Ashwagandha and Cyclizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ashwagandha has reported sedative properties and may add to the drowsiness caused by cyclizine. The clinical significance is uncertain and is based mainly on theoretical grounds.
How serious is the interaction between Ashwagandha and Cyclizine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to watch for excess drowsiness and avoid driving until they know how the combination affects them. Reduce or stop the herbal product if sedation is troublesome.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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