Drug interactions
Aspirin + Azilsartan-chlorthalidone
Severity: Moderate
Aspirin and Azilsartan-chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At analgesic or anti-inflammatory doses, aspirin can reduce the antihypertensive effect of ARBs and diuretics and may impair renal function, especially in elderly or volume-depleted patients. Low-dose cardioprotective aspirin has far less effect.
What this interaction means in plain words
Aspirin and Azilsartan-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces renal perfusion and promotes sodium and water retention.
What to do
Monitor blood pressure and renal function when higher doses of aspirin are used, and keep patients hydrated. Low-dose aspirin generally needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Aspirin with Azilsartan-chlorthalidone?
MediHelp rates the interaction as moderate. Aspirin and Azilsartan-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At analgesic or anti-inflammatory doses, aspirin can reduce the antihypertensive effect of ARBs and diuretics and may impair renal function, especially in elderly or volume-depleted patients. Low-dose cardioprotective aspirin has far less effect.
How serious is the interaction between Aspirin and Azilsartan-chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when higher doses of aspirin are used, and keep patients hydrated. Low-dose aspirin generally needs no change.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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