Drug interactions
Acetylsalicylic acid + Calcium carbonate
Severity: Minor
Acetylsalicylic acid and Calcium carbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate is an antacid that can alkalinise urine slightly, which increases renal excretion of salicylate. The effect is usually modest at antacid doses but may lower salicylate levels in patients on high-dose aspirin therapy.
What this interaction means in plain words
Acetylsalicylic acid and Calcium carbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Calcium carbonate belongs to Gastrointestinal Tract.
Why it happens
Urinary alkalinisation reduces tubular reabsorption of ionised salicylic acid, increasing its renal elimination.
What to do
No action is needed for low-dose aspirin. In patients on high-dose anti-inflammatory aspirin, watch for changes in efficacy or salicylate levels when starting or stopping regular antacids.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Acetylsalicylic acid with Calcium carbonate?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Calcium carbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium carbonate is an antacid that can alkalinise urine slightly, which increases renal excretion of salicylate. The effect is usually modest at antacid doses but may lower salicylate levels in patients on high-dose aspirin therapy.
How serious is the interaction between Acetylsalicylic acid and Calcium carbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for low-dose aspirin. In patients on high-dose anti-inflammatory aspirin, watch for changes in efficacy or salicylate levels when starting or stopping regular antacids.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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