Drug interactions
Atazanavir + Calcium carbonate
Severity: Moderate
Atazanavir and Calcium carbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir needs an acidic environment to dissolve, and calcium carbonate raises gastric pH. Reduced atazanavir exposure can lead to virologic failure and resistance.
What this interaction means in plain words
Atazanavir and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Calcium carbonate belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH decreases the solubility and absorption of atazanavir.
What to do
Give atazanavir at least 2 hours before or 1 hour after the antacid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
- Acalabrutinib + Calcium carbonate Moderate
- Alendronate + Calcium carbonate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium carbonate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium carbonate Moderate
- Atenolol + Calcium carbonate Moderate
- Azilsartan-chlorthalidone + Calcium carbonate Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Calcium carbonate?
MediHelp rates the interaction as moderate. Atazanavir and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir needs an acidic environment to dissolve, and calcium carbonate raises gastric pH. Reduced atazanavir exposure can lead to virologic failure and resistance.
How serious is the interaction between Atazanavir and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give atazanavir at least 2 hours before or 1 hour after the antacid.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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