Drug interactions
Aspirin + Candesartan-hydrochlorothiazide
Severity: Moderate
Aspirin and Candesartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin, especially at analgesic or anti-inflammatory doses, can blunt the antihypertensive effect of candesartan and the diuretic effect of hydrochlorothiazide. In volume-depleted or elderly patients, the combination of an ARB, diuretic and NSAID can impair renal function. Low-dose aspirin carries much less risk.
What this interaction means in plain words
Aspirin and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces renal blood flow and sodium excretion, opposing the ARB and diuretic and raising the risk of acute kidney injury.
What to do
Prefer low-dose aspirin when it is needed for cardioprotection and avoid regular high-dose use. Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Aspirin with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Aspirin and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin, especially at analgesic or anti-inflammatory doses, can blunt the antihypertensive effect of candesartan and the diuretic effect of hydrochlorothiazide. In volume-depleted or elderly patients, the combination of an ARB, diuretic and NSAID can impair renal function. Low-dose aspirin carries much less risk.
How serious is the interaction between Aspirin and Candesartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer low-dose aspirin when it is needed for cardioprotection and avoid regular high-dose use. Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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