Drug interactions
Acetylsalicylic acid + Clomipramine
Severity: Moderate
Acetylsalicylic acid and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a strongly serotonergic tricyclic and, like SSRIs, can add to aspirin's bleeding risk, especially in the upper GI tract. Clinically significant bleeding is uncommon but possible.
What this interaction means in plain words
Acetylsalicylic acid and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Clomipramine belongs to Central Nervous System.
Why it happens
Inhibition of platelet serotonin uptake impairs platelet aggregation, additive with aspirin's antiplatelet and mucosal effects.
What to do
Monitor for signs of bleeding, and consider gastroprotection with a proton pump inhibitor in patients with additional GI risk factors. Reassess the need for aspirin if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Acetylsalicylic acid with Clomipramine?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a strongly serotonergic tricyclic and, like SSRIs, can add to aspirin's bleeding risk, especially in the upper GI tract. Clinically significant bleeding is uncommon but possible.
How serious is the interaction between Acetylsalicylic acid and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, and consider gastroprotection with a proton pump inhibitor in patients with additional GI risk factors. Reassess the need for aspirin if bleeding occurs.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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