Drug interactions
Arsenic trioxide + Clomipramine
Severity: Contraindicated
Arsenic trioxide and Clomipramine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arsenic trioxide causes marked QT prolongation and has been linked to torsades de pointes. Clomipramine also prolongs QT, so the combination adds serious arrhythmic risk.
What this interaction means in plain words
Arsenic trioxide and Clomipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Clomipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation by effects on cardiac ion channels.
What to do
Avoid the combination and use an antidepressant with minimal QT effect. If it cannot be avoided, use close ECG and electrolyte monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Arsenic trioxide and Clomipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Clomipramine
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
- Clomipramine + Phenelzine Contraindicated
Other interactions of Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Arsenic trioxide + Fluphenazine Contraindicated
- Arsenic trioxide + Gemifloxacin Contraindicated
- Arsenic trioxide + Hydroxychloroquine Contraindicated
Frequently asked questions
Can I take Arsenic trioxide with Clomipramine?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Clomipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and has been linked to torsades de pointes. Clomipramine also prolongs QT, so the combination adds serious arrhythmic risk.
How serious is the interaction between Arsenic trioxide and Clomipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antidepressant with minimal QT effect. If it cannot be avoided, use close ECG and electrolyte monitoring.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Dofetilide, Droperidol, Isocarboxazid. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
