Drug interactions
Clomipramine + Droperidol
Severity: Contraindicated
Clomipramine and Droperidol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combining with clomipramine increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Clomipramine and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Avoid the combination and use a non-QT-prolonging antiemetic or sedative. If unavoidable, obtain a baseline ECG, correct electrolytes and monitor the rhythm.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
- Clomipramine + Phenelzine Contraindicated
Frequently asked questions
Can I take Clomipramine with Droperidol?
MediHelp rates the interaction as contraindicated. Clomipramine and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combining with clomipramine increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Clomipramine and Droperidol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antiemetic or sedative. If unavoidable, obtain a baseline ECG, correct electrolytes and monitor the rhythm.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Isocarboxazid. The full list is on the Clomipramine page.
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