Drug interactions
Clomipramine + Pentamidine
Severity: Contraindicated
Clomipramine and Pentamidine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and systemic pentamidine has been associated with torsades de pointes. Combined use raises the risk of life-threatening ventricular arrhythmia.
What this interaction means in plain words
Clomipramine and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clomipramine belongs to Central Nervous System; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization through effects on cardiac ion channels.
What to do
Avoid concurrent use; choose a non-QT-prolonging alternative for one of the drugs. If pentamidine is essential, withhold clomipramine where feasible and monitor ECG and electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Phenelzine Contraindicated
Other interactions of Pentamidine
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
- Pentamidine + Thioridazine Contraindicated
Frequently asked questions
Can I take Clomipramine with Pentamidine?
MediHelp rates the interaction as contraindicated. Clomipramine and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and systemic pentamidine has been associated with torsades de pointes. Combined use raises the risk of life-threatening ventricular arrhythmia.
How serious is the interaction between Clomipramine and Pentamidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose a non-QT-prolonging alternative for one of the drugs. If pentamidine is essential, withhold clomipramine where feasible and monitor ECG and electrolytes.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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