Drug interactions
Acetylsalicylic acid + Dicloxacillin
Severity: Minor
Acetylsalicylic acid and Dicloxacillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are highly protein bound and salicylates may theoretically displace penicillins or reduce their renal tubular secretion, but no clinically meaningful change in dicloxacillin effect is well documented. Any effect is likely small.
What this interaction means in plain words
Acetylsalicylic acid and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Dicloxacillin belongs to Anti Bacterial.
Why it happens
Possible competition for plasma protein binding and renal tubular secretion.
What to do
No routine action is needed; monitor clinical response to antibiotic therapy as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Acetylsalicylic acid with Dicloxacillin?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Dicloxacillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are highly protein bound and salicylates may theoretically displace penicillins or reduce their renal tubular secretion, but no clinically meaningful change in dicloxacillin effect is well documented. Any effect is likely small.
How serious is the interaction between Acetylsalicylic acid and Dicloxacillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor clinical response to antibiotic therapy as usual.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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