Drug interactions
Cholera vaccine + Dicloxacillin
Severity: Moderate
Cholera vaccine and Dicloxacillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine contains a live bacterial strain that systemic antibiotics may reduce or kill. This may blunt the immune response to the vaccine.
What this interaction means in plain words
Cholera vaccine and Dicloxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces replication and immunogenicity.
What to do
Do not give the vaccine within 14 days after oral or parenteral antibiotics, per labeling. Postpone vaccination until the antibiotic course is complete.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
- Dicloxacillin + Doxycycline Moderate
Frequently asked questions
Can I take Cholera vaccine with Dicloxacillin?
MediHelp rates the interaction as moderate. Cholera vaccine and Dicloxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine contains a live bacterial strain that systemic antibiotics may reduce or kill. This may blunt the immune response to the vaccine.
How serious is the interaction between Cholera vaccine and Dicloxacillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine within 14 days after oral or parenteral antibiotics, per labeling. Postpone vaccination until the antibiotic course is complete.
What other medicines interact with Dicloxacillin?
MediHelp also lists interactions of Dicloxacillin with, for example, Phenindione, Atogepant, Axitinib. The full list is on the Dicloxacillin page.
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