Drug interactions
Acetylsalicylic acid + Edoxaban
Severity: Major
Acetylsalicylic acid and Edoxaban: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin taken with edoxaban increases the risk of bleeding, including clinically relevant and major bleeds. The combination is sometimes used in patients with vascular disease but requires caution.
What this interaction means in plain words
Acetylsalicylic acid and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Edoxaban belongs to Cardiovascular.
Why it happens
Additive hemostatic impairment from platelet inhibition by aspirin and factor Xa inhibition by edoxaban, plus aspirin-induced mucosal injury.
What to do
Reserve the combination for clear indications, use low-dose aspirin for the shortest period, and consider a proton pump inhibitor. Monitor for bleeding and avoid chronic high-dose aspirin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Argatroban + Edoxaban Major
- Aspirin rectal + Edoxaban Major
Frequently asked questions
Can I take Acetylsalicylic acid with Edoxaban?
MediHelp rates the interaction as major. Acetylsalicylic acid and Edoxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aspirin taken with edoxaban increases the risk of bleeding, including clinically relevant and major bleeds. The combination is sometimes used in patients with vascular disease but requires caution.
How serious is the interaction between Acetylsalicylic acid and Edoxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for clear indications, use low-dose aspirin for the shortest period, and consider a proton pump inhibitor. Monitor for bleeding and avoid chronic high-dose aspirin.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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