Drug interactions
Edoxaban + Ketorolac
Severity: Contraindicated
Edoxaban and Ketorolac: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac impairs platelet function and damages gastric mucosa while edoxaban is an anticoagulant, so major bleeding risk is considerably increased. Ketorolac labeling contraindicates its use in patients at risk of bleeding and with anticoagulants.
What this interaction means in plain words
Edoxaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Edoxaban belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment from NSAID platelet inhibition and factor Xa inhibition.
What to do
Avoid ketorolac with edoxaban and use a non-NSAID analgesic; if exposure occurs, monitor for bleeding and hemoglobin changes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
- Aspirin rectal + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Ketorolac?
MediHelp rates the interaction as contraindicated. Edoxaban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac impairs platelet function and damages gastric mucosa while edoxaban is an anticoagulant, so major bleeding risk is considerably increased. Ketorolac labeling contraindicates its use in patients at risk of bleeding and with anticoagulants.
How serious is the interaction between Edoxaban and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac with edoxaban and use a non-NSAID analgesic; if exposure occurs, monitor for bleeding and hemoglobin changes.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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