Drug interactions
Aspirin + Enalapril-hydrochlorothiazide
Severity: Moderate
Aspirin and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of ACE inhibitors and thiazides and can impair renal function, especially in volume-depleted or elderly patients. With a diuretic plus an ACE inhibitor, the risk of acute kidney injury is higher. Low-dose aspirin for cardioprotection carries less risk than analgesic doses.
What this interaction means in plain words
Aspirin and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandin synthesis reduces renal perfusion and antagonizes antihypertensive effects.
What to do
Prefer low-dose aspirin where aspirin is indicated and avoid regular analgesic doses; monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Aspirin with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Aspirin and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood pressure lowering effect of ACE inhibitors and thiazides and can impair renal function, especially in volume-depleted or elderly patients. With a diuretic plus an ACE inhibitor, the risk of acute kidney injury is higher. Low-dose aspirin for cardioprotection carries less risk than analgesic doses.
How serious is the interaction between Aspirin and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer low-dose aspirin where aspirin is indicated and avoid regular analgesic doses; monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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