Drug interactions
Acetylsalicylic acid + Fondaparinux
Severity: Major
Acetylsalicylic acid and Fondaparinux: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin combined with fondaparinux raises the risk of bleeding because both impair hemostasis through different pathways. The risk is greater with higher aspirin doses and in older or renally impaired patients.
What this interaction means in plain words
Acetylsalicylic acid and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Fondaparinux belongs to Cardiovascular.
Why it happens
Additive effects of antiplatelet action of aspirin and indirect factor Xa inhibition by fondaparinux.
What to do
Avoid unless dual therapy is clearly indicated; use low-dose aspirin and monitor for bleeding, hemoglobin and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Alteplase + Fondaparinux Major
- Apixaban + Fondaparinux Major
Frequently asked questions
Can I take Acetylsalicylic acid with Fondaparinux?
MediHelp rates the interaction as major. Acetylsalicylic acid and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aspirin combined with fondaparinux raises the risk of bleeding because both impair hemostasis through different pathways. The risk is greater with higher aspirin doses and in older or renally impaired patients.
How serious is the interaction between Acetylsalicylic acid and Fondaparinux?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless dual therapy is clearly indicated; use low-dose aspirin and monitor for bleeding, hemoglobin and renal function.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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