Drug reference
fondaparinux
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Thrombotics)
Mechanism of action
Antithrombotic agent; inhibits factor Xa, which interrupts blood coagulation cascade and inhibits thrombin formation and thrombus development; generally does not increase prothrombin time (PT) or partial thromboplastin time (PTT)
Common side effects
- Rash
- Anemia
- Dizziness
- Nausea
- Fever
- Confusion
Boxed warnings
- Black Box Warnings Epidural or spinal hematomas may occur in patients undergoing anticoagulation with low-molecular-weight heparins (LMWHs) or heparinoids who receive neuraxial (epidural or spinal) anesthesia or spinal puncture These hematomas may result in long-term or permanent paralysis Patients should be frequently monitored for signs and symptoms of neurologic impairment If neurologic compromise is noted, urgent treatment is necessary Physicians should weigh benefits against risk before embarking on neuraxial intervention in patients anticoagulated or scheduled to be anticoa…
Contraindications
- Severe renal impairment (CrCl <30 mL/min) Body weight <50 kg (venous thromboembolism prophylaxis only) Active major bleeding Bacterial endocarditis Thrombocytopenia with antiplatelet antibody in presence of fondaparinux History of serious hypersensitivity reaction (eg, angioedema, an…
Known interactions (13)
- abciximab + fondaparinux Major
- apixaban + fondaparinux Major
- bazedoxifene-conjugated estrogens + fondaparinux Major
- cilostazol + fondaparinux Major
- clopidogrel + fondaparinux Major
- eptifibatide + fondaparinux Major
- fondaparinux + mifepristone Major
- fondaparinux + rivaroxaban Major
- fondaparinux + ticlopidine Major
- anagrelide + fondaparinux Moderate
- dipyridamole + fondaparinux Moderate
- estradiol + fondaparinux Moderate
- fondaparinux + tirofiban Moderate
Related conditions
Frequently asked questions
What drug class is fondaparinux?
fondaparinux belongs to: Cardiovascular.
How does fondaparinux work?
Antithrombotic agent; inhibits factor Xa, which interrupts blood coagulation cascade and inhibits thrombin formation and thrombus development; generally does not increase prothrombin time (PT) or partial thromboplastin time (PTT)
What are the common side effects of fondaparinux?
Rash, Anemia, Dizziness, Nausea, Fever, Confusion
Which drugs interact with fondaparinux?
abciximab, apixaban, bazedoxifene-conjugated estrogens, cilostazol, clopidogrel, eptifibatide, mifepristone, rivaroxaban, ticlopidine, anagrelide, dipyridamole, estradiol, tirofiban
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