Drug interactions
Fondaparinux + Ketorolac
Severity: Contraindicated
Fondaparinux and Ketorolac: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac impairs platelet function and can cause GI bleeding, while fondaparinux is a factor Xa inhibitor anticoagulant, so major bleeding risk increases. Ketorolac labeling contraindicates use in patients at risk of bleeding.
What this interaction means in plain words
Fondaparinux and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fondaparinux belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment from NSAID platelet inhibition and indirect factor Xa inhibition.
What to do
Avoid ketorolac with fondaparinux and use a non-NSAID analgesic; if exposed, monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
- Apixaban + Fondaparinux Major
Frequently asked questions
Can I take Fondaparinux with Ketorolac?
MediHelp rates the interaction as contraindicated. Fondaparinux and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac impairs platelet function and can cause GI bleeding, while fondaparinux is a factor Xa inhibitor anticoagulant, so major bleeding risk increases. Ketorolac labeling contraindicates use in patients at risk of bleeding.
How serious is the interaction between Fondaparinux and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac with fondaparinux and use a non-NSAID analgesic; if exposed, monitor for bleeding and hemoglobin.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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